Head-up tilt test with clomipramine challenge in vasovagal syndrome—a new tilt testing protocol
نویسندگان
چکیده
منابع مشابه
Head-up tilt test with clomipramine challenge in vasovagal syndrome--a new tilt testing protocol.
PURPOSE The aim of the study was to randomly compare clomipramine, used as a challenge-agent during head-up tilt test, with isoproterenol, used in the conventional test, in patients with vasovagal syndrome. SUBJECTS AND METHODS The serotonergic re-uptake inhibitor clomipramine was infused (5mg in 5min) at the start of head-up tilt test (Clom-HUT) in 126 patients (mean age 41+/-16 years) with ...
متن کاملProvocation of neurocardiogenic syncope by clomipramine administration during the head-up tilt test in vasovagal syndrome.
OBJECTIVES We sought to test the hypothesis that activation of the serotonergic system in patients with vasovagal syndrome during the head-up tilt test provokes syncope. BACKGROUND Central serotonergic activation participates in the pathogenesis of neurocardiogenic syncope. Drugs increasing serotonin (5-HT) in the central nervous system have not been tested as drug challenges during the head-...
متن کاملRecurrent vasovagal syncope: comparison between clomipramine and nitroglycerin as drug challenges during head-up tilt testing.
AIMS To compare the responses between clomipramine, a centrally acting substance, and nitroglycerin, with mainly peripheral action, when each drug is used during tilt test for the induction of vasovagal syncope (VVS). METHODS AND RESULTS Hundred patients with recurrent episodes of classical VVS underwent two tilt tests in a randomized sequence. One test included 20 min of tilt at 60 degrees w...
متن کاملEndogenous Circadian Rhythm in Vasovagal Response to Head-Up Tilt
Background—The incidence of syncope exhibits a daily pattern with more occurrences in the morning, possibly as a result of influences from the endogenous circadian system and/or the daily pattern of behavioral/emotional stimuli. This study tested the hypothesis that the circadian system modulates cardiovascular responses to postural stress, leading to increased susceptibility to syncope at spec...
متن کاملHead-up tilt testing in children.
The article by Kouakam et al. in issue 22/17 is a prospective observational study of syncope recurrence in 101 children (mean age 12·6 3; range 7–18 years) undergoing head-up tilt testing for investigation of recurrent unexplained syncope or presyncope. Data are presented for patients recruited between 1990 and 1998, and followed-up for an average of 4 years. Head-up tilt was initially positive...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2003
ISSN: 0195-668X
DOI: 10.1016/s0195-668x(02)00821-7